Pascal is harnessing the powerful combination of click chemistry and some of the brightest minds in materials science to solve unmet needs across healthcare.
CLICKGEL
ClickGel is a specialized hydrogel developed through the Nobel Prize-winning field of click chemistry. But unlike traditional click chemistry, ClickGel is formulated without a copper catalyst, making it safe for biological applications and giving it several unique characteristics.
Biodegradable and nontoxic
• Does not elicit an inflammatory response
• Controlled and full absorption
Injectable
• Can be placed wherever a needle can reach
• Conforms to anatomy
Wide Range of Applications
• Tissue sealing
• Drug delivery
• Countless others
The result is an extremely versatile and safe material that can be placed virtually anywhere in the human body to create precise and targeted effects before completely dissipating.
DURAL SEALANT
Approximately 1.2M dural repairs are performed annually in the US/EU during cranial and spinal procedures.
ClickGel is ideally suited for this application.
Anatomy-Conforming
Molds precisely to the surgical site
Suture-Free
No stitching required for placement
Non-Toxic
Safe for use in sensitive neural environments
Rapidly biodegrades
Naturally resorbs in the body
Watertight Seal
Reliably prevents leakage
after closure
Non-Swelling
Reduces risk of nerve compression in spinal procedures
Injectable Application
Can be used for open or minimally invasive procedures
DRUG DELIVERY
The unique characteristics of ClickGel make it an ideal carrier to deliver drugs precisely where they are needed. Projects currently in development include:
Bone formation
ClickGel impregnated with Bone Morphogenetic Protein (BMP) can be injected into bony defects or fusion sites to promote bone growth.
Infection prevention and treatment
ClickGel can deliver antibiotics to surgical sites virtually anywhere in the body without impacting surrounding tissues.
Publications &
Presentations
Publication:
Rapidly Polymerizing Click Hydrogel Provides Localized Delivery of rhBMP2 to promote Bone Formation
Presentation:
D. Joshua Cohen, Thomas W. Jacobs, D. Scott Wilson,
Michael C. Mancini, Christine Van Duyn, Zvi Schwartz, Barbara D. Boyan
Military Health System Research Symposium
August 6, 2025
Kissimmee, FL
CLICK CHEMISTRY EXPLAINED
A recent Nobel-winning technology, click chemistry is a powerful and versatile set of chemical reactions that allows for the rapid and reliable formation of targeted molecules. The term “click” refers to the ease and simplicity of these reactions, which “snap” molecular building blocks together like a puzzle piece.
Click chemistry is characterized by:
Precision
Click reactions are highly selective, meaning they will primarily react with one specific functional group, minimizing unwanted reactions.
Efficiency
These reactions typically generate high yields and minimal side products, making them efficient and ideal for small-scale and large-scale applications.
Versatility
Because the reactions are modular, they can be used to build complex molecules by simply changing one or two components, offering flexibility in molecular design.
Biocompatibility
Click reactions generally occur in mild conditions, including biological systems, making them useful in biochemistry and surgical treatment applications.
